Clariant Plastics & Coatings Healthcare Polymer Solutions is adding a new oxygen-scavenging additive masterbatch to its MEVOPUR line of medical-grade materials and services for pharmaceutical packaging and medical devices.
MEVOPUR ProTect is effective at limiting oxygen (O2) degradation of drugs and neutraceuticals stored in polyethylene terephthalate (PET) bottles, even in a transparent mono-layer construction.
The new masterbatch concentrate and other innovations are being introduced at Pharmapack Europe.

Steve Duckworth, Global Head of Marketing & Business Development for Clariant Healthcare Polymer Solutions, said: “Just as in food and beverage packaging PET is becoming more widely used, but while food and beverages require a relatively short shelf life, pharmaceuticals often need to maintain their potency even when stored for a year or more.
"Although HDPE has been the material of choice, PET offers several advantages, including transparency, and the MEVOPUR ProTect additives help to combine transparency with long-term shelf-life. And, while recycling is not yet a major topic in pharma, PET is considered a highly recyclable material, and any oxygen barrier that does not require multiple layers is going to be an advantage.”
Originally developed to overcome the deficiencies of existing oxygen barrier systems used in food and beverage packaging, the active molecules showed very high performance in scavenging oxygen permeating through container walls, and thereby maintains extremely low levels of O2 over extended periods even in a mono-layer and refrigerated storage.
The protection offered by the oxygen scavenging system depends on a number of factors including packaging design, additive loading, and target oxygen levels over time.
However, by way of illustration, Clariant testing of 500ml monolayer PET bottles with 3.6% loading of the masterbatch concentrate was able to maintain oxygen levels below 1 ppm for more than 590 days, compared to just 22 days for untreated PET, and 63 days for a competitive oxygen scavenger.
Protection of the drug is not the only area where MEVOPUR ProTect could offer a solution in O2 protection.
Duckworth said: “In diagnostic applications, oxygen can interfere with the sample/reagent combination, affecting the accuracy of the analytics. Therefore, we expect some interest in MEVOPUR ProTect in these PET applications as well.”